Asthma Quality of Life Questionnaire

Exacerhations, Asthma Control Questionnaire (ACQ), Asthma Quality of Life Questionnaire (AQLQ) and lower respiratory tract infections... 

The overall effectiveness of Xolair treatment was clearly reflected in measures of the asthma-related quality of life. Patient s self-assessment of asthma-related quality of life, using the validated asthma-related quality-of-life questionnaire (AQLQ) (16), showed a clinically significant change from baseline of 0.5 units improvement in both treatment groups for all domains at the end of both treatment stabilization and steroid-reduction periods. Importantly, a significantly greater improvement over placebo was seen in Xolair-treated patients for each of the individual domains (activities, emotions, symptoms, environmental exposure) and overall scores (p = 0.02). 

Components of the assessment of control include symptoms, nighttime awakenings, interference with normal activities, pulmonary function, quality of life, exacerbations, adherence, treatment-related adverse effects, and satisfaction with care. The categories of well controlled, not well controlled, and very poorly controlled are recommended. Validated questionnaires can be administered regularly, such as the Asthma Therapy Assessment Questionnaire, Asthma Control Questionnaire, and Asthma Control Test. 

Juniper EF, Guyatt GH, Epstein RS, et al. Evaluation of impairment of health related quality of life in asthma development of a questionnaire for use in clinical trials. Thorax 1992 47 76-83. 

Cook DJ, Guyatt GH, Juniper E, et al. Interviewer versus self-administered questionnaires in developing a disease-specific, health-related quality of life instrument for asthma J Qin Epidemiol 1993 46 529-534. 

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