Assessment of Preclinical Positive Signals

The authors want to acknowledge Laszlo Urban, Mats Holmqvist, Berengere Dumotier and John Davies for reviewing this chapter. [Pg.406]

1 Fung, M. (2001) Evaluation of the characteristics of safety withdrawal of prescription drugs from worldwide pharmaceutical markets-1960 to 1999. Drug Information Journal, 35, 293-317. [Pg.406]

2 Kannel, W.B., Cupples, L.A. and D Agostino, R.B. (1987) Sudden death risk in overt coronary heart disease The Framingham Study. American Heart Journal, 113, 799-804. [Pg.406]

3 CAST (1989) Preliminary report effect of encainide and flecainide on mortality in a randomized trial of arrhythmia suppression after myocardial infarction. The cardiac arrhythmia suppression trial (CAST) investigators. The New En and Journal of Medicine, 321, 406 12. [Pg.406]

4 Hanton, G. (2007) Preclinical cardiac safety assessment of drugs. Drugs R D, 8, 213-228. [Pg.406]

Big Chemical Encyclopedia