Aspirin aluminium

A polymeric condensation product of aluminium oxide and aspirin which contains about 83% of total salicylates. 

A number of aluminium aspirin preparations have also been described, to which different structures have been assigned . One of these compounds, aluminium aspirin NF, was found to be poorly absorbed compared with acetylsalicylic acid. Aloxiprin (Palaprin) is a different form of aluminium aspirin, being a polymeric condensation product of aluminium oxide and acetylsalicylic acid, with the formula Al302(C8H4(o-OCMe)-COO)s 9B. This compound is therapeutically as effective as acetylsalicylic acid it produces less gastric irritation and gastro-intestinal blood loss, but has a slight tendency to cause constipation. ... 

In vitro data show that magnesium oxide and aluminium hydroxide strongly adsorb aspirin and sodium salicylate. However, in three of the studies above aluminium hydroxide-containing antacids had no effect on the extent of absorption of salicylate, although the rate of absorption may be increased as a result of an increase in the solubility of salicylate in a less acidic gastric environment. ... 

An aluminium/magnesium hydroxide antacid (Maalox) and AlkaSelt-zer (aspirin, calcium phosphate, citric acid and sodium bicarbonate) do not significantly affect the absorption of cefixime, ... 

Obtained by Fries rearrangement of 2-(acetyloxy)-benzoic acid (Aspirin) (1 mol) in the presence of aluminium chloride (3.3 mol),... 

Transfer to a 250-ml separator about 100 mg of aluminium aspirin, accurately weighed, add 40 ml of freshly prepared sodium fluoride-hydrochloric acid solution (dissolve 500 mg of sodium fluoride in 100 ml of O IN hydrochloric acid) and shake for five minutes. Allow the solution to stand for ten minutes with frequent shaking. Extract with eight portions, each of 20 ml, of chloroform, filtering each extract into a 200-ml graduated flask, dilute to volume with chloroform and mix. Dilute 20 ml of this solution to 100 ml w ith chloroform and measure the extinc-... 

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