Asperger’s disorder

Language and speech. Speech spontaneity, articulation, vocabulary, and prosody should be noted. Pedantic speech may be a symptom of Asperger s disorder or of a nonverbal learning disorder. Diminished speech may be the result of depression or autism. Excessive speech may be the result of anxiety, ADHD, or hypo-mania. Unusual speech may be an early sign of neu-rodevelopmental vulnerability to psychosis. Slurred speech may be evidence of a neurologic abnormality or a medication side effect. 

Hollander E, Novotny S, Hanratty M, Yaffe R, DeCaria CM, Aronowitz BR, Mosovich S (2003) Oxytocin infusion reduces repetitive behaviors in adults with autistic and Asperger s disorders. Neuropsychopharmacology 28 193-198. 

Pervasive developmental disorders, including childhood autism, are described in the ICD-10. Asperger s syndrome (ICD-10) and Asperger disorder (DSM-IV) are likewise included in both diagnostic systems. 

A possible interaction of risperidone with tetracycline has been reported in a 15-year-old adolescent with Asperger s syndrome, Tourette s syndrome, and obsessive-compulsive disorder (274). Acute exacerbation of motor and vocal tics occurred when tetracycline 250 mg bd was introduced for acne withdrawal of tetracycline resulted in an improvement in the tics. 

A 15-year-old youth with Asperger s syndrome, Tourette s syndrome, and obsessive-compulsive disorder was stabilized on risperidone 1.5 mg bd and sertraline 100 mg od and had marked improvement in his social skills and tics, until he was given tetracycline 250 mg bd for acne. Within 2 weeks his tics were acutely exacerbated with pronounced neck jerking and guttural sounds. The sertraline was increased to 150 mg/day, but the tics did not resolve. The tetracycline was withdrawn after 1 month, and the tics improved within a few weeks. 

Autism—(or other pervasive developmental disorder such as Asperger s syndrome) characterized by severe deficits in social interactions, language, and/or thinking or ability to learn, and usually diagnosed... 

Amino acid decarboxylase Classic autism Asperger s syndrome Adenosine-triphosphate Childhood disintegrative disorder Central nervous system Carboxyl group... 

Presumed lithium-related renal insufficiency occurred in a 13-year-old boy with bipolar disorder, Asperger s syndrome, and attention deficit hyperactivity disorder, who had taken lithium for over 5 years [51" ]. He had congenital absence of one kidney and previously had one episode of mild lithium toxicity. Kidney biopsy showed membranous glomerulonephropathy, which may have been related to lithium or to another kidney condition. 

Baron-Cohen S, Wheelwright S (2004) The empathy quotient an investigation of adults with Asperger syndrome or high functioning autism, and normal sex differences. 1 Autism Dev Disord 34 163-175. 

Today, autism terminology includes pervasive development disorder (PDD), or autism spectrum disorder (ASD), which in turn comprises five diagnostic categories autism, Rett syndrome, Asperger syndrome, childhood disintegrative disorder, and pervasive developmental disorder not otherwise specified (PDD-NOS). PDD is also called broad autism, while the more severe autism per se is called narrow autism, as illustrated in John s case. 

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