Ascorbate potentiated cytotoxicity

Ascorbate Potentiated Cytotoxicity of Nitroaromatic Compounds. Extensive research aimed at finding chemicals or chemical systems that will sensitize hypoxic cells, which are ordinarily very resistant to radiation or chemicals, is being conducted in the field of radiobiology. Of particular interest are the investigations (58-6J) of the catalytic effect of certain carcinogens upon the oxidation of ascorbate. 4-Nitroquinoline N-oxide (4-NQO), which is one of many compounds (52,62,63) that mediate the ascorbate-oxygen reaction, is used as an example. 

Clinically important, potentially hazardous interactions with aluminum hydroxide, antacids, ascorbic acid, bone marrow suppressants, chloroquine, cytotoxic agents, food, gold, hydroxychloroquine, iron, magnesium, primaquine, probenecid... 

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