Asbestos, respiratory toxicity

Respiratory protective equipment for use against asbestos Momtonng strategies for toxic substances Carbon monoxide... 

Medically evaluating, training, qualifying, and fit-testing workers for specific respirator types, checking 29 CFR 1910, Subpart Z, Toxic and Hazardous Substances, for any special respiratory protection requirements (e.g., for asbestos, lead, or cadmium) [3]... 

McConnell EE, Chevalier HJ, Hesterberg TW, et al. 1994. Comparison of the effects of chrysotile and crocidolite asbestos in rats after inhalation for 24 months. In Mohr U, Dungworth DL, Mauderly JL, et al., ed. Toxic and carcinogenic effects of solid particles in the respiratory tract. Washington, DC ILSI Press, 461-467. 

Mossman BT. 1983. In vitro approaches for determining mechanisms of toxicity an carcinogenicity by asbestos in the gastrointestinal and respiratory tracts. Environ Health Perspect 53 155-161. 

What are the molecular events involved in the development of asbestos-induced respiratory and pleural effects and how are they influenced by fiber dimensions and mineral type Identification of the molecular and cellular events of asbestos-induced disease has been the subject of extensive research within the past two decades (see Mechanisms of Asbestos Toxicity Overview section). However, much remains unknown, and the precise steps in pathogenic pathways are not frilly established. 

Mossman B, Light W, Wei E. 1983. Asbestos mechanisms of toxicity and carcinogenicity in the respiratory tract. Annii Rev Pharmacol Toxicol 23 595-615. 

For classification of carcinogens in categories 1 and 2, the danger symbol T with the danger identification toxic and the R-phrases 45 or 49 have to be used. R 49 Hmits usage in which there is an inhala-tive cancer risk of the respiratory tract caused from dust, fibers, or H-quid aerosols. Typical examples are asbestos, chromium(Vl) compounds, and cadmium chloride. 

By 20.12, there will be books on the uses of nanoparticles and there are already hundreds of research papers. There may also be books discussing the toxicity of these materials. The asbestos fibers linked to respiratory illness have widths <250nm amphibole (red or blue asbestos) fibers are -75—240 nm wide, therefore definitely counting as nanoparticles. 

Respiratory protection is the most critical aspect of all protective clothing. The most common exposure route is the respiratory system. Most chemical agents are dispersed as an aerosol vapor or, in the case of biological or radiological agents, as small particles suspended in an aerosol. The atmosphere at explosion scenes will be very dusty (fine airborne particles). Working at an explosion scene requires respiratory protection, as this dust may contain asbestos or other toxic materials. 

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