Generalized argyria

Possibility of generalized argyria in 20 years 2 Argyrosis of cornea and conjunctiva 3... 

Generalized argyria evident 2 years after last 2 dose... 

Dermal. Medical case histories indicate that dermal exposure to silver or silver compounds for extended periods of time can lead to local skin discoloration similar in nature to the generalized pigmentation seen after repeated oral exposure. However, the amount of silver and the duration of time required to produce this effect cannot be established with the existing information (Buckley 1963 McMahon and Bergfeld 1983). Moreover, adverse effects such as argyria have not been associated with the use of silver sulphadiazine as a bactericidal agent (Fox et al. 1969). No studies were located regarding dermal effects in animals after dermal exposure to silver or silver compounds. 

The majority of literature reviewed concerning the health effects of silver in humans described case reports of individuals who developed argyria following oral exposure to silver. Occupational studies describing two separate worker populations were also located. The predominant route of exposure in the occupational studies is believed to have been inhalation, but the possibility of some degree of oral or dermal exposure cannot be ruled out. Information on human exposure is limited in that the possibility of concurrent exposure to other toxic substances cannot be excluded, and the duration and level of exposure to silver generally cannot be quantitated from the information presented in these reports. 

Dupont T, Gomez J, Cuvillier P, et al. 1984. [Drug-induced generalized argyria. Value of blood and urine analysis. Apropos of 2 cases], IARC Medical 4 103-105. (French). 

Pariser RJ. 1978. Generalized argyria Clinicopathologic features and histochemical studies. Arch Dermatol 114 373-377. 

Pezzarossa E, Alinovi A, Ferrari C. 1983. Generalized argyria. J Cutan Pathol 10 361-363. 

Prose PH. 1963. An electron microscopic study of human generalized argyria. Am J Pathol 42 293-299... 

---