Arginine salt

Dolobis (Merck Sharp Dohme-Chibret 1981) Dolobid (Morson 1978) Adomal (Malesci) Aflogos (Biomedica Foscama as arginine salt)... 

S)-(-)-9-Fluoro-6,7-dihydro-8-(4-hydroxypiperidin-l-yl)-5-methyl-l-oxo-l//,5//-benzo[i,j]quinolizine-2-carboxylic acid 1-arginine salt tetrahydrate. 

Clinical use Diflunisal (Brogden et al., 1980) is a nonsteroidal anti-inflammatory drug used in the treatment of mild to moderate pain including osteoarthritis, rheumatoid arthritis and primary dysmenorrhoea. It is used as base or lysine- or arginine-salt for oral or parenteral application. 

Indomethacin is available as the sodium, meglumine, or L-arginine salt or as the prodrug (proglumetacin maleate). 

In the present directions, Method i is essentially that developed by Bergmann and Zervas 6 Method 2 forms a combination of methods (b and c) and thus at once affords a product of high purity, while avoiding the mechanical difficulties involved in the complete removal of the dinitronaphtholsulfonic acid from its arginine salt. 

In a study of a cytokine formulation, sulfates and a range of arginine salts were found to be effective in generating more than a 10-fold increase in solubility (Flores et ak, 2001). Unexpectedly, solubility increased with increasing sulfate concentrations, and the protein crystallized in sulfate formulations at low temperatures. These studies also indicated that counter ions of arginine with two or... 

Monosuccinate arginine salt, CuHMCI3N(0,n, chloramphenicol arginine succinate, Paraxln Succinate A. mp 135 -145 (dec ). See Japan. Med. Gaz. 7(10), 15 (1970), Cinnamate, Cloromilen. 

Eto B, Le Moel G, Porquet D, Peres G. Glutamate-arginine salts and hormonal responses to exercise. Arch Physiol Biochem 1995 103 160-164. 

Figure 4A Structure of peptido-cellulose conjugate oriented with the amino-terminal portion of the sequence anchored to carboxymethylcellulose allowing solution solvation for binding of the elastase recognition sequence illustrating active site uptake of elastase, B Structure depicting arginine salt bridge from the protein surface with carboxylate group of carboxymethylcellulose.

---