Arachidonate Modulation of Protein Kinase

PKC is a family of protein kinase isozymes which are thought to be present in, and essential for, the functioning of virtually all 

Direct effects of non-esterified arachidonate on membrane ion channels  

ChannelType K+ channels Outward rectifier Effect Concentration m 

Gastric smooth muscle Transient outward Activation 10-100 

An interesting case of synaptic modulation that may depend upon arachidonate stimulation of PKC activity has been reported by Immaculada Herrero, Jose Sanchez-Prieto and their coworkers at the Universidad Complutense in Madrid.Glutamatergic nerve terminals isolated from the rat brain express a metabotropic sub-type of the glutamate receptor that is coupled to inositol phospholipid metabolism and PKC activation. Stimulation of nerve 

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