AR, Androgen receptor

Note PCa, prostate cancer WM, white male DES, diethylstilbestrol AR, androgen receptor PSA, prostate specific antigen and PAP, prostatic acid phosphatase. 

ER Estrogen Receptor, AR Androgen Receptor, GR Glucocorticoid Receptor, TR Thyroid Receptor, RAR Retinoic Acid Receptor, RXR Retinoie X Receptor, PR Progesterone Receptor, VDR Vitamin D Receptor, PPAR Peroxisome Proliferator-Activated Receptor, PXR Pregnane X Receptor, ROR Retinoic Acid-Related Orphan Receptor, NHF-4 Hepatocyte Nuclear Eactor 4, ERR Estrogen-Related Receptor... 

Figure 23-8 Functional domains of the steroid hormonere ceptors. AR, androgen receptor ER. estrogen receptor. GR, glucocorticoid receptor. MR. mineralocorlicoid receptor and F progesterone receptor.

Xql2 186.59 AR Androgen receptor 313700 Spinal and bulbar muscular atrophy of Kennedy, prostate cancer, complete androgen insensitivity, hypospadia type 1... 

Fig. 129.4 Mode of acticm of lycopene to contribute to reduced canc risk. IGF-I insulin-like growth factor I, IL 6 int leukin 6, AR androgen receptor, T testosterone, DfTT S-a-dihydiotestostennie, 80H-dG 8-hydroxy-2 -deoxyguanosine, and ARE antioxidant-response element (Frran Wertz et al. [33])...

AR Androgen receptor ER Estrogen receptor FLIP Fluorescence loss in photobleaching FRAP Fluorescence recovery after photobleaching FRET Fluorescence resonance energy transfer GR Glucocorticoid receptor NER Nucleotide excision repair UV Ultra-violet... 

Sex steroid receptors are members of the steroid hormone receptor (SHR) family that ligand-dependently regulate functions of the sexual organs. Sex steroid receptors are the androgen receptor [1] (AR), the estrogen receptor a [2] and (3 [3] (ERa, ER 3), and the progesterone receptor [4] (PR). 

Sex Steroid Receptors Androgen Receptor, Estrogen Receptors, Progesterone Receptor. Figure 1 Schematic structures of AR, ERa, ER(3, and PR. 

OMIM (Online Medelian Inheritance in Man) www. ncbi.nlm.nih.gov/entrez 313700 ANDROGEN RECEPTOR AR... 

Tip60 Fluman H2A, H3, H4, cMYC, androgen receptor (AR) DNA repair, apoptosis... 

Structural modifications of bicalutamide led to the discovery of the first generation of selective androgen receptor modulators (SARMs). These compounds not only bind to the AR with an affinity in the nanomolar range, but they also show tissue selectivity in animal models [206]. 

By considering the SARs observed in bioassays with knowledge of the crystal structure of receptor-androgen receptor interactions, Fang et al. [30] were able to make statements about the chemical structures most likely to be associated with binding to the AR. These are summarized in Table 18.3. 

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