Phenobarbital Aprepitant

APREPITANT ANTI EPILEPTICS -CARBAMAZEPINE, PHENOBARBITAL, PHENYTOIN 1 aprepitant levels Induction of CYP3A4-mediated metabolism of aprepitant Watch for poor response to aprepitant... 

Clinically important, potentially hazardous interactions with amlodipine, anisindione, anticoagulants, aprepitant, atorvastatin, barbiturates, benzodiazepines, butabarbital, carbamazepine, chlordiazepoxide, clarithromycin, clonazepam, dorazepate, corticosteroids, cyclosporine, dexamethasone, diazepam, dicumarol, erythromycin, ethotoin, felodipine, flurazepam, fluvastatin, fosphenytoin, isradipine, itraconazole, ketoconazole, lorazepam, lovastatin, mephenytoin, mephobarbital, midazolam, nicardipine, nifedipine, nimodipine, nisoldipine, oxazepam, pentobarbital, phenobarbital, pimozide, pravastatin, primidone, quazepam, rifampin, secobarbital, simvastatin, St John s wort, temazepam, warfarin... 

Clinically important, potentially hazardous interactions with amprenavir, aprepitant, atazanavir, carbamazepine, chlorpheniramine, cimetidine, clarithromycin, clorazepate, CNS depressants, darunavir, delavirdine, dexamethasone, efavirenz, erythromycin, esomeprazole, fluconazole, fluoxetine, fosamprenavir, grapefruit juice, griseofulvin, imatinib, indinavir, itraconazole, ivermectin, ketoconazole, lopinavir, nelfinavir, nevirapine, phenobarbital, phenytoin, primidone, rifabutin, rifampin, ritonavir, roxithromycin, saquinavir, St John s wort, telithromycin, tipranavir... 

Clinically important, potentially hazardous interactions with alcohol, aprepitant, clarithromycin, cyclosporine, fluconazole, ketoconazole, phenobarbital, rifampin, ritonavir, St John s wort, verapamil... 

Although not assessed, this marked leduetion in aprepitant levels could result in reduced eflieaey. In the UK, the manufacturer recommends that concurrent use of aprepitant and strong indueers of CYP3A4, such as rifampicin, be avoided. They also name phenytoin (see also Aprepitant + CYP2C9 substrates , above), carbamazepine, and phenobarbital, and... 

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