Applying Metabonomics in Biological Sciences Toxicological Research

APPLYING METABONOMICS IN BIOLOGICAL SCIENCES TOXICOLOGICAL RESEARCH 

Metabonomics has received considerable attention in the toxicological community, but based on published literature, metabonomic applications do not appear to be as widely used as transcriptomics (toxicogenomics). However, this is not a reflection on the utility of the approach, but more likely a consequence of the need to have a complex infrastructure, particularly with respect to data analysis and interpretation in order to carry out the technology. 

With respect to preclinical studies, one interesting observation determined in metabonomic studies, is that vehicles used for compound administration are not biologically inert, and may influence the analysis of metabonomic data. In fact, some commonly used vehicles for compound administration are not compatible with metabonomics applications, most notably Labrofil and polyethylene glycol (21). Finally, because NMR is 

Metabonomics Mito stress 70 protein pi ATP synthesis a chain Heats shock protein (HSP) 10 HSP 60 Mitochondrial thioredox-dependent peroxide reductase Mitochondrial matrix protein pi 

Liver-MAS Triglycerides Glucose, glycogen Alanine Phospholipids 

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