Applications of NO Donors

Clinical Cardiovascular Applications of NO Donor Therapy - Past and Present... 

S. M. Aldoshin (Director). This session included four presentations. Professor N.P. Konovalova reported on antioxidants and donors of nitrogen monoxide (antitumor effects of nitroxides and NO-donors) the report of N.A. Sanina and S.M. Aldoshin was concerned with a new class of NO-donors (synthesis, structure, properties, and practical use of sulfur-nitrosyl complexes of iron). Free-radical mechanisms of induction and development of secondary necrosis after gun wounds were the subject of the lecture by G.N. Bogdanov L.D. Smirnov reported on pharmacological properties and promising clinical application of antioxidants of the heteroaromatic array. 

Sialylations of 77 were achieved in good yield and stereoselectivity by using phenylsulfenyl trifiate (PST) as a promoter and di-tert-butylpyridine (DTBP) as a proton scavenger. The most impressive application of this donor was for the synthesis of the a-2,3-linked disaccharide 78, which proceeded in 78% yield with no trace of the j8 isomer (Scheme 24). It was also demonstrated that the auxiliary could be efficiently removed by reduction with BusSnH and AIBN in 94% yield. 

Activation of K ca channels following application of NO or NO donors has also been reported to be mimicked by an activator of the cGMP-dependent protein kinase (Archer et al., 1994), suggesting that the pathway linking NO with K ca channel activation is cGMP dependent. 

Rose Ml, Mascharak PK (2008) Photoactive ruthenium nitrosyls effects of light and potential application as NO donors. Coord Chem Rev 252 2093-2114... 

NO-releasing biomaterials have been developed for antibacterial applications including polymeric materials, xerogel, sol gel,i i and silica nanoparticles. Two different classes of NO donors, diazeniumdiolates and nitrosothiols, are commonly used. The diazeniumdiolates, also called as NONOates, are synthesized by reaction of amines with NO gas to form relatively stable compounds that spontaneously release NO on contact with bodily fluids. 

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