NO donors

Heterocycles as exogenic NO donors and inhibitors of its formation 97E339, 97E627, 97UK792. 

Nitroglycerin has long been used for the treatment of acute attack of angina pectoris, and its stable analogs are available to prevent the anginal attack. Nitrovaso-dilators such as sodium nitropmsside liberate NO from their molecules in the tissue (thus, called NO donors) and elicit actions via cyclic GMP like those seen with endogenously synthesized NO. 

Over the last 15 years, the munber of patent registrations and commercial products concerned with the Bfx and Fx use as NO donor agents has increased extremely [156-160]. 

In order to improve the properties of the well-known adrenergic antagonist, two chemical modulations on classical drugs including NO-donor moiety have been described. On the one hand, chemical modifications on Prazosin, an a 1-adrenergic antagonist, including furoxanyl moieties have been reported [70,182,183]. hi this approach, the 2-furanylcarbonyl moiety of Pra-... 

The NO donor, C87-3754, reportedly attenuates the injury induced in cats by splanchnic artery occlusion of the coeliac, superior mesenteric and inferior mesenteric... 

The Ni111 state is more easily attained with the NOS donor-set ligand (75a) (i 1/2 = +0.75V vs. SCE) compared to the N02 analogue (75b), the latter showing only an ill-defined anodic... 

The unsymmetric phenolato-derived ligand (749) bearing a tridentate N20 donor set and a bidentate NO donor set has produced a trinuclear Ni11 complex that incorporates two unusual... 

Ribeiro, A. C. Kapas, L. (2003). Intra-suprachiasmatic nucleus (SCN) microinjection of a nitric oxide (NO) donor and NO synthase inhibitor affects sleep in rats. 

Nitric oxide (NO) is an intercellular signaling molecule that can inhibit neuronal energy production (Brorson et al., 1999 Malefic et al., 2004). It has been found that NO donors cause large increases in extracellular adenosine in cultures of forebrain neurons (Rosenberg et al., 2000). These were shown to be caused by NO release, and the accumulation of adenosine was not blocked by probenecid (ENT blocker) or GMP (a blocker of AMP hydrolysis), suggesting that adenosine was likely of intracellular origin. Indeed, it was found that NO donors caused a decrease in intracellular ATP and the inhibition of adenosine kinase activity, possibly due to the rise in adenosine. 

The well-known method of furazan formation is based on nitrosation of alkenes. Thus, several NO donor 3,4-disubstituted 1,2,5-oxadiazole 2-oxide derivatives and the related 1,2,5-oxadiazoles, containing methylsulfonylphe-nyl, phenylsulfonyl, sulfonylamidophenyl, and phenylsulfonylamido groups were synthesized by nitration of... 

S-nitrosothiols (RSNO) have emerged as important species in the storage and transport of nitric oxide. As NO donors these S-N compounds have potential medical applications in the treatment of blood circulation problems. 

Lompre Normally endothelial cells have SERCA2B and SERCA3. Liu et al (1997) showed that SERCA3-defective mice have the same defect in relaxation that you describe. If they add NO donors, they also restore relaxation as for TRP4. Could it be that there is a relationship between this pool of Ca2+ SERCA3 and TRP4 ... 

Nitrosonium (NO+) is a strong oxidant and the reduction potential to NO has been measured in non-aqueous media (1.67 V vs. SCE in CH3CN), and estimated for water (Eq. (3)) (12,15). NO+ is subject to rapid hydrolysis to nitrite (2H+ + N02 ), and therefore if formed in biological media would be short-lived. However, other less water-sensitive chemical species can act as NO+ donors in reactions leading to the nitrosation of various substrates. For example, the reactions of certain metal nitrosyl complexes with nucleophiles such as R SH can lead to the transfer of NO+ as illustrated in Eq. (4). Such reactions will be discussed in greater detail below. 

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