Applications of Fischer Indolizations

2 31 Dru Tar ets drugs. This section illustrates many of these drugs and drug 

Perhaps more than any other indole ring synthesis, the the Introduction. This section is organized by disease and/ 

Fischer indolization has proved to be of paramount or receptor target. 

Human papillomaviruses (HPVs) cause a variety of benign and premalignant tumors, and several infect the genitalia. HPV infections are the most widespread sexually transmitted disease worldwide, with nearly 6 million new 

Like the battle against viruses, the war to stop bacterial and parasitic infections has reached the critical stage, with multidrug-resistant bacteria, such as methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus faecalis (VRE), killing thousands of people annually in the United States [196]. Likewise, tuberculosis (TB) has killed about 1 billion people worldwide over the past two centuries. Some 3.5 milUon people in India are currently infected with TB [197]. 

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Application of Fischer indole synthesis to ketone CXXI or its open chain precursor CXX resulted in the formation of 12If-indolo[2,3-a]-pyridocolinium salts substituted at the 2-position (CXXII) 53). 

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