Applications drug delivery agents

Dendrimers are a special class of arborescent monodisperse nanometer sized molecules that have been used in the synthesis of Au NPs as surface stabilizers or nanoreactor/templates for nanoparticle growth. Moreover, these hybrid nanomaterials have great potential for application in different fields such as sensors, imaging in cells, electrooptical devices, catalysis, drug delivery agents, and so on. 

Ross, B. P., DeCruz, S. E., Lynch, T. B., Davis-Goff, K., and Toth, 1. (2003) Design, Synthesis and evaluation of a liposaccharide drug delivery agent application to the gastrointestinal absorption of gentamicin. J. Med. Chem. 47,1251-1258. 

Fullerenes are another carbon-based nanomaterial that may be exposed to aquatic environments. There has been increased commercial interest in Ceo (buckybaUs) for a variety of applications, including fuel cells and drug delivery agents. There is a lack of knowledge relating to environmental and health effects of Ceo, but concern is rising due to fullerene s ability to bind and cleave DNA and inhibit enzyme activity (64, 65). 

Applications in Medicine MRI Contrast Agents and Drug Delivery Agents... 

The hydrosilylation of unsaturated polymers (e.g, polybutadiene, polyiso-prene, polyesters, polyenes, and polycarbonates) with a silane having hydrolyzable substituents at silicon atoms leads to polymeric systems with enhanced activity toward mineral fillers (32). Such process also offers a useful and convenient method for preparing silane-modified polymers that may find potential applications as rubber materials, adhesives, and drug delivery agents. Both >C=C< as well >C=0 bonds are capable of hydrosilylation. This modification is connected with a reversed use of the silane (siloxane) coupling agents. Trialkoxysilyl groups are commonly incorporated onto the polymers by Pt-catalyzed hydrosilylation... 

Taken as a group, the polymeric systems facilitate vast differences in binding and mode of function through multivalent action. Some applicability has been found, as described above, and additional applications in areas such as the development of sensors, therapeutics, diagnostics, and drug delivery agents will doubtless be forthcoming. 

The aqueous solubility enhancement of guests with potential medicinal or pharmaceutical applications such as those mentioned previonsly has led to significant research into the use of CB[n] hosts as drug delivery agents. Macartney has published an excellent recent review of (he encapsnlation of drug molecules by cucurbiturils, and the effect of inclusion on their physical and chemical properties, inclnding solubiUty [14],... 

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