Application of Cytokine Assays

Pharmaceutical Approaches to Interfering with Cytokines and Their Receptors 

Cytokines Corticosteroid MAPK inhibitors Humanized antibodies Antisense oligonucleotides Soluble receptors 

Cytokine receptors Receptor antagonist Humanized antibodies Antisense oligonucleotides 

Intracellular Signal Transduction Molecules as Potential Therapeutic Targets 

Transcription factor NF-/cB and activator protein-1 (AP-1) (L10) are also important in the orchestration of asthmatic inflammation. This has prompted the search for specific blockers of transcription factors such as NF-kB. The protea-some inhibitor A-cbz-Leu-Leu-leucinal, MG-132, a specific inhibitor for NF-kB activation (F3), has been found to suppress chemokine IL-8 release from epithelial cells. However, its use for treating allergic inflammation requires further investigation (Table 6). 

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This volume continues our objective of expanding the intellectual horizon of clinical chemistry. Included are chapters on Clinical Applications of Cytokine Assays Diagnosis and Treatment of Acute Pancreatitis Mitochondrial Mutations and Mitochondrial Diseases Pathobiochemistry of Nephrotic Syndrome Total Antioxidant Capacity Autoantibodies to dsDNA, Ro/SSA, and LaSSB in Systemic Lupus Erythematosis and Lymphoid Malignancies and Immunosuppressive Analysis. The meld of analytical, anatomical, subcellular, and molecular sciences represented by these subjects will continue to evolve and expand. Clinical chemistry is a vibrant and vital profession. Future volumes, their editors, and their contributors will undoubtedly be an important part of the practice and science of clinical chemistry. 

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