Antitumor-promotor

Fig. (43). Antitumor promotor activity of ursolic and oleanoic acid...

Some foods originated from Liliaceae plants, such as Allium sat/vum(garlic) and A. wakegi are effective in the prevention of a malignant tumor and a sterol, laxogenin was identified as the active compound , in vitro Antitumor promotor test of the steroidal glycosides isolated by our studies have been carried out and the activity was estimated from the rate of incorporation of phospholipid into HeLa ceils stimulated with TPA(12-0-tetradecanoylphorbol 13-acetate). 

In a previous paper [1], we reviewed the isolation of quassinoids, alkaloids, and fatty acids from Simaroubaceous plants during the period 1972-1988 and discussed their biological activities, such as antitumor, antimalarial, and anti-inflammatory agents as well as insect antifeedants, amoebicides, and herbicides. This review will add new quassinoids isolated from Simaroubaceous plants from 1988 onwards and their biological activities, for example, antitumor, anti-tumor-promotor (= inhibitor against TPA-induced EBV-EA activation), anti-HIV, anti-tuberculosis, and insect antifeedant activities. Furthermore, the stability of quassinoids, lower activities of degradation products, and the synthesis of fluorinated quassinoids are also described. 

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