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Antitrypanosomals

Antitrypanosomal Drugs. Table 1 Different treatment strategies depending on the cause of hyperthyroidism... [Pg.192]

The hexanuclear Ir111 complex [L IrCl2cp 6], in which L is based on the amino glycoside neomycin B (249), has been characterized by IR, 13C, and 31P NMR spectroscopy, and by FAB Ms419 The in vivo antitumor and antitrypanosomal effects of [IrY4Cl2]1 complexes,... [Pg.194]

The in vivo antitumor and trypanocidal effects of dimeric [Irn2(CH3COO)4(L)ra]° (L = classical organic antimalarial drugs, n= 1, 2) are reported.494 The dimeric complexes are characterized by IR spectroscopy. Further studies of monomeric Ir11 complexes, IrnL2, where L = alkyl or aryl dithiocarbamates and xanthates, reveal no clear relation between antitumor and antitrypanosomal actvities.495 Structure-activity data for the Ir11 complexes is presented. [Pg.203]

Hoet S, Stevigny C, Block S, et al. Alkaloids from Cassytha filiformis and related apor-phines antitrypanosomal activity, cytotoxicity, and interaction with DNA and topoisomerases. Planta Med 2004 70 407-413. [Pg.224]

A,1 and the antitrypanosomal drug berenilJ Some of these are also alkylating agents that contain double bonds to which such groups as the 2-NH2 of guanine may add ... [Pg.224]

There was particular interest in the analogous reactions of 1-Oacetyl-2,3,5-tri-0-benzoyl-4-bromo-/ -D-ribose (37), because of the potential to prepare from it compounds related to nucleocidin, which is a 4 -fluoroaden-osine derivative having antitrypanosomal activity. With silver fluoride in acetonitrile, this bromide also reacted mainly with inversion of configuration, and gave the l-lyxo fluoride 140 (53% isolated yield), whereas, with silver tetrafluoroborate, much more of the more interesting 1-0-acetyl-2,3,4-tri-0-benzoyl-4-fluoro-/ -D-ribose (141) was obtained.38... [Pg.80]

DNAH (E. coli) (AChE, DNA, DNAS, RNAS, TOPII) [antitrypanosomal, antitumour]... [Pg.363]

HIV-1 RT RNase H [weak antitrypanosomal anti-plasmodial] HIV-1 RT (84nM) [inhibits HIV-1 replication (40nM)] [Metabolic conversion to the nucleoside triphosphate (NTP) (or equivalent) and RT-catalysed incorporation into DNA of the NMP (or equivalent) gives DNA chain termination because of the absence of a 3 -hydroxyl]... [Pg.386]

Nitidine Antileukemic to mouse, L1210, P388 cells Antitrypanosomal — 300... [Pg.35]

Among other activities, investigations were concerned with radio-protective effects (83MI3), antitrypanosomal activity (80JMC578), and amplifiers of phleomycin (85AJC1685). Pyridazines were shown to be potent tyrosine hydroxylase dopamine /3-hydroxylase inhibitors (83MI11). [Pg.437]

Compounds (21-23) illustrate further examples of nonclassical bioisosteres. Compound (21) was reported to display antitrypanosomal activity (18). The analogs (22) and (23) also displayed antitrypanosomal activity (19). Compound (22) demonstrated the most impressive activity (IC50 values of 40 and... [Pg.694]

See other pages where Antitrypanosomals is mentioned: [Pg.192]    [Pg.192]    [Pg.192]    [Pg.1486]    [Pg.171]    [Pg.255]    [Pg.385]    [Pg.175]    [Pg.365]    [Pg.366]    [Pg.367]    [Pg.386]    [Pg.294]    [Pg.225]    [Pg.552]    [Pg.693]    [Pg.936]    [Pg.121]    [Pg.1195]    [Pg.1195]    [Pg.6]    [Pg.316]    [Pg.747]    [Pg.748]    [Pg.359]    [Pg.371]    [Pg.491]    [Pg.192]    [Pg.192]    [Pg.192]    [Pg.29]    [Pg.719]    [Pg.719]   
See also in sourсe #XX -- [ Pg.6 ]



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