Antitetanus vaccine

Drago F, Rampini P, Lugani C, Rebora A. Generalized morphoea after antitetanus vaccination. CUn Exp Dermatol 1998 23(3) 142. 

Holmstrom et al. (1989b) evaluated the long-term inhalation effects of formaldehyde exposure to immune function in female Sprague-Dawley rats exposed to 12.6 ppm formaldehyde for 6 hours/day, 5 days/week for 22 months. After 22 months of formaldehyde exposure, the rats were inoculated subcutaneously with Pneumovax (Merck Sharpe and Dohme) and antitetanus vaccine (National Bacteriological Laboratory). Animals were sacrificed at 21-25 days after vaccination. Blood samples were collected from each animal before vaccination and just prior to sacrifice. Tlie blood was analyzed for response to Pneumovax and tetanus vaccination using an enzyme-linked immunosorbant assay technique. The results indicated... 

Historically, horse immunoglobulins have been of interest because of the use of horse antiserums, such as antitetanus toxin or antidiphtheria toxin, for therapeutic purposes. These are less widely employed now owing to the advent of antibiotics, the development of improved vaccines, and the hazards of serum sickness associated with inoculation of horse proteins into patients. Horse immunoglobulins are less thoroughly characterized, with respect to amino acid sequence, than mouse and human immunoglobulins, in part because equine myeloma proteins are not available. 

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