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Antisense therapy

Antisense therapy means the selective, sequence-specific inhibition of gene expression by single-stranded DNA oligonucleotides. By hybridizing to the target mRNA, which results in a subsequent double-helix formation, gene expression is blocked. This process can occur at any point between the conclusion of transcription and initiation of translation or even possibly during translation. [Pg.185]

TABLE 3.1 Selected Antisense Therapies In Clinical Development... [Pg.82]

Particles from cationic lipids may also be useful for antisense therapy of skin disease — a nontoxic increase in the oligonucleotide uptake by cultivated keratinocytes and a sebocyte cell line has been reported [66]. Moreover, cationic dendri-mers also efficiently transfer reporter gene DNA to human keratinocytes cultivated in vitro. In the skin of hairless mice, in vivo transfection was possible with complexes, yet reporter gene expression was localized to perifollicular areas. Transfection, however, failed with the naked plasmid. For prolonged contact, biodegradable membranes coated with dendrimer/DNA complexes were used [67]. This hints at a follicular uptake of these complexes and indicates that gene transfection also may be possible with human skin, which has a thicker stratum comeum compared with mouse skin (eight to ten vs. two to three layers [58]). [Pg.12]

The above described studies show that the renal proximal tubular cell is a good target for antisense therapy [135],... [Pg.148]

Elez R, Piiper A, Kronenberger B et al (2003) Tumor regression by combination antisense therapy against Plkl and Bel-2. Oncogene 22 69-80... [Pg.302]

Webb A, Cunningham D, Cotter F, et al. Bcl-2 antisense therapy in patients with non-Hodgkin lymphoma. Lancet 1997 349 1137-1141. [Pg.337]

Nyce W, Metzger W (1997) DNA antisense therapy for asthma in an animal model. Nature 385(6618) 721-725... [Pg.230]

The literature reviewed here show that both formulated and unformulated (simple aqueous solution) ASO can be delivered to the lungs, where they subsequently suppress local gene expression, opening a wide variety of diseases to antisense therapy. [Pg.252]

Clinical implications and first experience of antisense therapy... [Pg.375]

First clinical experience of antisense therapy in the treatment of restenosis... [Pg.376]

Bennett MR, Schwartz SM, Antisense therapy for angioplasty restenosis some critical considerations, Circulation 1995 92 1981-1993. [Pg.378]

Pawlak W, Zolnierek J, Sarosiek T, Szczylik C (2000) Antisense therapy in cancer. Cancer Treat Rev 26 333-350... [Pg.86]

Lastly, although antisense therapy is considered a simple and efficient procedure, its products have never reached the market. This is due to the instability of phos-... [Pg.501]


See other pages where Antisense therapy is mentioned: [Pg.186]    [Pg.408]    [Pg.553]    [Pg.554]    [Pg.80]    [Pg.80]    [Pg.351]    [Pg.149]    [Pg.68]    [Pg.171]    [Pg.166]    [Pg.106]    [Pg.496]    [Pg.30]    [Pg.30]    [Pg.32]    [Pg.40]    [Pg.41]    [Pg.45]    [Pg.67]    [Pg.439]    [Pg.561]    [Pg.374]    [Pg.375]    [Pg.370]    [Pg.18]    [Pg.228]    [Pg.496]    [Pg.219]    [Pg.186]   
See also in sourсe #XX -- [ Pg.295 ]

See also in sourсe #XX -- [ Pg.171 ]

See also in sourсe #XX -- [ Pg.12 , Pg.44 ]

See also in sourсe #XX -- [ Pg.429 ]




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