Antiparasitics topical

Because of the outbreak of antimony-resistant leishmania sis and the need to develop an oraky-adrninistered therapy, the use of many other compounds has been considered. Those that appear to have clinical utility ate aHoputinol (62), ketoconazole (63), and both systemicaHy and topically applied paromomycin (8) (see Antiparasitic agents, antimycotics). 

Medicinals. Many esters are used as pharmaceuticals (105,106). Of these, benzocaine, ethyl 4-aminobenzoate [94-09-7] is a topical anesthetic. Phenyl saHcylate [118-55-8] (1) has antipyretic, antirheumatic, and antiparasitic properties. 

The crude drug is used for the treatment of peptic ulcers, diuresis, as an antipyretic, an analgesic, and an antiparasitic. In Japan, it was formerly used for killing maggots, and for prickly heat. An extract of the whole plant was applied as a topical insecticide for cattle, and as an insecticide for plants. 

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