Parenteral preparations antioxidants

Monothioglycerol is used as an antioxidant in pharmaceutical formulations, mainly in parenteral preparations. Monothioglycerol is reported to have some antimicrobial activity. It is also widely used in cosmetic formulations such as depilating agents. 

If sodium bisulfite is to be used as an antioxidant in parenteral preparations, the legal situation in the respective country must be considered. 

Sodium metabisulfite is used as an antioxidant in oral, parenteral, and topical pharmaceutical formulations, at concentrations of 0.01-1.0% w/v. Primarily, sodium metabisulfite is used in acidic preparations for alkaline preparations, sodium sulfite is usually preferred see Section 18. Sodium metabisulfite also has some antimicrobial activity, which is greatest at acid pH, and may be used as a preservative in oral preparations such as syrups. 

Sodium sulfite is used as an antioxidant in applications similar to those for sodium metabisulfite It is also an effective antimicrobial preservative, particularly against fungi at low pH (0.1% w/v of sodium sulfite is used). Sodium sulfite is used in cosmetics, food products, and pharmaceutical applications such as parenteral formulations, inhalations, oral formulations, and topical preparations. 

VI.I.2.2.3. pages 1-5 Covers homopolymer and copolymer. Limit of not more than three stabilisers (antioxidants) from a list of nine. Polypropylene for containers for preparations for parenteral use. (1990)... 

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