Antioxidants donor

Selenium is an essential element and is beneficial at low concentrations, serving as an antioxidant. Lack of selenium affects thyroid function, and selenium deficiencies have been linked to Keshan Disease (34). Selenium at high levels, however, is toxic. Hydrogen selenide (which is used in semiconductor manufacturing) is extremely toxic, affecting the mucous membranes and respiratory system. However, the toxicity of most organ oselenium compounds used as donor compounds for organic semiconductors is not weU studied. 

The basis to the chain breaking donor (CB—D) mechanism, which was the first antioxidant mechanism to be investigated, was laid down by the late 1940s [10-12]. Many reducing agents, e.g., hindered phenols and aromatic amines, which reduce the ROO to hydroperoxide in a CB—D step have already been empirically selected and used for rubbers and by this time also for the newer plastics industry (e.g., Table la, AO 1-8 and 9-12). The major mechanistic landmarks of the antioxi-... 

Another approach to safer stabilization is to use a biological antioxidant such as vitamin E (a-tocopherol is the active form of vitamin E, AO-9, Table la). It is essentially a hindered phenol which acts as an effective chain breaking donor antioxidant, donating a hydrogen to ROO to yield a very stable tocopheroxyl radical, a-Tocopherol is a very effective melt stabilizer in polyolefins that offers high protection to the polymer at very low concentration [41], (Table 2). 

Adducts other than N bases are thiourea,909 phosphine,880 and N,0-donors (hydroxyquinoline derivatives).910 In the last case NiONS2 complexes were formed. Generally, complexes of dithiophosphates are used as antiwear and antioxidant additives. 

Zinc dithiocarbamates have been used for many years as antioxidants/antiabrasives in motor oils and as vulcanization accelerators in rubber. The crystal structure of bis[A, A-di- -propyldithio-carbamato]zinc shows identical coordination of the two zinc atoms by five sulfur donors in a trigonal-bipyramidal environment with a zinc-zinc distance of 3.786 A.5 5 The electrochemistry of a range of dialkylthiocarbamate zinc complexes was studied at platinum and mercury electrodes. An exchange reaction was observed with mercury of the electrode.556 Different structural types have been identified by variation of the nitrogen donor in the pyridine and N,N,N, N -tetra-methylenediamine adducts of bis[7V,7V-di- .vo-propyldithiocarbamato]zinc. The pyridine shows a 1 1 complex and the TMEDA gives an unusual bridging coordination mode.557 The anionic complexes of zinc tris( V, V-dialkyldithiocarbamates) can be synthesized and have been spectroscopically characterized.558... 

Figure 32 Disappearance and appearance kinetics of transcellular flux of the lipophilic antioxidant PNU-78,517 (pKa 6.5) across MDCK cell monolayers in Transwell systems at 37°C. Donor solutions contained 3% bovine serum albumin (BSA), and receiver solutions contained 0.5-5% BSA at pH 7.4. [Redrawn from Raub et al. (1993) with permission from the publisher.]... 

A check of the results of the parameter ACP of human blood plasma after removal of low-molecular-weight antioxidants by means of gel filtration was positive and showed a clear difference between the results in healthy donors and cancer patients, as can be seen in Figure 16 [35],... 

It has been proposed [91] that nitric dioxide radical formation during the oxidation of nitrite by HRP or lactoperoxidase (LPO) can contribute to tyrosine nitration and be involved in cell and tissue injuries. This proposal was supported in the later work [92] where it has been shown that N02 formed in peroxide-catalyzed reactions is able to enter cells and induce tyrosyl nitration. Reszka et al. [93] demonstrated that N02 mediated the oxidation of biological electron donors and antioxidants (NADH, NADPH, cysteine, glutathione, ascorbate, and Trolox C) catalyzed by lactoperoxidase in the presence of nitrite. 

Low-density lipoproteins in plasma and arterial wall are susceptible to oxidation to form oxidized LDL, which are thought to promote the development of atherosclerosis. LDL particles have a density of about 1.05, a molecular weight of about 2.5 x 106, and a diameter of about 20 nm [119]. LDL composition from different donors varies widely an average LDL particle contains about 1200 molecules of unsaturated acids and antioxidants about six molecules of a-tocopherol, about 0.53 molecule of 7-tocopherol, about 0.33 molecule of (3-carotene, and about 0.18 molecule of lycopene [120], Rapid oxidation of LDL is started only after the depletion of tocopherols and carotenoids [121]. 

Methionine (Met or M) ((5)-2-amino-4-(methylsulfanyl)-butanoic acid) is a nonpolar, neutral, amino acid with the formula HOOCCH(NH2)CH2CH2SCH3. Together with Cys, Met is one of the two sulfur-containing proteinogenic amino acids and a great antioxidant. Its derivative 5-adenosyl methionine (SAM) serves as a methyl donor. ... 

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