Antineoplastic agents neuropathy caused

Chemotherapy is a common method of treatment for many types of cancer. The side effects of chemotherapy come about in part because cancer cells are not the only dividing cells in the body. Chemotherapeutic agents cause increased production of free radicals that can be harmful for normal cells, and these free radicals can be bound by antioxidant vitamins and supplements, including lycopene. A large number of studies have reported the beneficial effects of a variety of antioxidants in antineoplastic agents-induced nephrotoxicity, hepatotoxicity, ototoxicity, and peripheral neuropathy [218, 219]. Chemoprotective activities of lycopene [219, 220], and other dietary components that scavenge free radicals induced by exposure to antineoplastic agents [218, 220] have been well documented (Table 129.2). 

Antineoplastic plant alkaloid cell cycle (M phase)-specific agent inhibits mitotic spindle formation. Tox peripheral neuropathy. Vinblastine, a congener, causes myelosuppression. 

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