Antimotion sickness

Qian DS, Liu ZS. (1992). [Pharmacologic studies of antimotion sickness actions of ginger]. Chung Kuo Chung Hsi I Chieh Ho Tsa Chih. 12(2) 95-8, 70. 

Antimotion sickness effect. Ginger and other medications were compared with sco-... 

ZO003 Wood, C. D., J. E. Manno, M. J. Wood, B. R. Manno, and M. E. Mims. Comparison of efficacy of ginger with various antimotion sickness drugs. Clin Res Pr Drug Regul Aff 1988 6(2) 129-136. 

Antimotion sickness effect Several Hj-antagonists have significant property in preventing motion sickness. This effect was first observed with drug, dimenhydrinate and subsequently with other drugs like diphenhydramine, promethazine and other piperazine derivatives. 

Diphenhydramine Competitive antagonism at Hi receptors Reduces or prevents histamine effects on smooth muscle, immune cells also blocks muscarinic and adrenoceptors highly sedative IgE immediate allergies, especially hay fever, urticaria some use as a sedative, antiemetic, and antimotion sickness drug Oral and parenteral t duration 4-6 h Toxicity Sedation when used in hay fever, muscarinic blockade symptoms, orthostatic hypotension Interactions Additive sedation with other sedatives, including alcohol some inhibition of CYP2D6, may prolong action of some 13 blockers... 

Several of the older generation antihistamines are used exclusively for situations that do not involve an allergic reaction. For example, some demonstrate significant antiemetic, antimotion sickness, antiparkinsonian, antitussive, and local anesthetic actions (some Hj antagonists are more potent than procaine). They can be found in many OTC products, particularly for the relief of symptoms from the common cold and allergies, as well as by prescription. The effectiveness of the agents in the treatment of motion sickness and Parkinson s disease may be attributed to their anticholinergic actions. 

Scopolamine Antimotion sickness, causes sedation and short-term memory block j... 

In the phenothiazine area, it has been amply demonstrated that structural changes, in addition to producing expected quantitative changes in tranquilizing activity, also produce unexpected qualitative changes in biological activity. As a result antipruritic, antispasmodic, anticonvulsant, antibacterial, antiemetic, antimotion sickness, anthelmintic, and antidepressant compounds have been developed by molecular modification of the phenothiazines. 

Compound XX has antimotion sickness properties and some stimulant effects, but is relatively devoid of tranquilizing properties (18). 

Cao SL, Zhang QZ, Jiang XG. Preparation of ion-activated in situ gel systems of scopolamine hydrobromide and evaluation of its antimotion sickness efficacy. Acta Pharmacol Sin. 28 (4) 584-590, 2007. 

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