Antimicrobial Ascomycetes

Stadler M et at. New metabolites with nematicidal and antimicrobial activities from the ascomycete Lachnum papyraceum (Karst.) Karst. VII. Structure determination of brominated lachnumon and mycorrhizin A derivatives, J Antibiot 48 158-161, 1995. 

Anke H. etal., Secondary metabolites with nematicidal and antimicrobial activity from nematophagous fungi and Ascomycetes, Can J Bot 73 S932—S939, 1995. 

Stadler M, Anke H, Sterner O (1995) Metabolites with Nematicidal and Antimicrobial Activities from the Ascomycete Lachnum papyraceum (Karst.) Karst V. Production, Isolation and Biological Activities of Bromine-Containing Mycorrhizin and Lachnumon Derivatives and Four Additional New Bioactive Metabolites. J Antibiot 48 149... 

The structure determination of lachnumon (193), brominated derivatives of lachnumon (194) and mycorrhizin (195) and brominated derivatives of mycorrhizin A (196) was described. The compounds, which exhibit similar antimicrobial and nematocidal activities as their chlorinated analogues, were isolated from extracts of cultures of the ascomycete Lachnum papyraceum to which CaBr2 had been added [219]. 

The naphthalene derivatives (171, 172), from Daldinia concentrica (Ascomycetes), were significantly active towards C. elegans (10, 25 (ig/ml) and also showed antimicrobial and cytotoxic activity [6]. Since the black fruiting bodies of D. concentrica are highly melanized, it is likely that these compounds arise from melanin biosynthesis. Some naphthoquinones have been found to inhibit the motility and survival of H. contortus (LI). Plumbagin ( 173) was the most potent (ED 1 ig/ml) followed by 1, 4-naphthoquinone, juglone (174) and 1, 2-naphthoquinone [281]. 

Stadler, M. and Anke, H., Lachnumon and lachnumol, a new metabolites with nematicidal and antimicrobial activities from the ascomycete Lachumm papyraceum (KARST.) KARST. 

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