Antimicrobial Antiprotozoal

The occurrence in some plants of secondary metabolites characterized by an 0-heterocyclic structure and exhibiting antimicrobial properties is a well-known phenomenon [2,8-10]. Among them, catechins and proanthocyanidins are two classes of compounds exhibiting antimicrobial properties towards both prokaryotic and eukaryotic microorganisms. Yet, despite the large number of studies published so far, the real potentialities and limitations given by the use of this class of molecules as antiviral or antimicrobial (antibacterial, antimycotic, antiprotozoal) agents have not been critically evaluated. The present chapter represents an overview of the re-... 

Chapter 50 Miscellaneous Antimicrobial Agents Disinfectants, Antiseptics, Sterilants Chapter 51 Clinical Use of Antimicrobial Agents Chapter 52 Antiprotozoal Drugs... 

Encamacion DR, Franzblau SG, Tapia CA, Cedillo-Rivera R (2000) Screening of Marine Organisms for Antimicrobial and Antiprotozoal Activity. Pharm Biol 38 379... 

Traditionally, Garcinia species have been used as anti-inflammatory, anti-immunosuppressive, antiprotozoal and antimicrobial agents. The various medicinal properties attributed to Garcinia are ... 

Folate analogs such as trimethoprim have potent antibacterial and antiprotozoal activity. Trimethoprim binds lO -fold less tightly to mammalian dihydrofolate reductase than it does to reductases of susceptible microorganisms. Small differences in the active-site clefts of these enzymes account for its highly selective antimicrobial action. The combination of trimethoprim and sulfamethoxazole (an inhibitor of folate synthesis) is widely used to treat infections. 

ANTIMICROBIAL with ANTIBACTERIAL and ANTIPROTOZOAL actions. It widely used orally for a range of bacterial and protozoal infections. It acts as a potent aldehyde DEHYDROGENASE INHIBITOR, which can lead to Significant interactions with other drugs. It is also a diamine oxidase INHIBITOR. 

When considering use of antimicrobial (antibacterial, antifungal, antiprotozoal, and antiviral) prophylaxis in neutropenic patients with cancer, the risks and benefits of the prophylaxis versus issues with development of resistance, toxicities, and other concerns must be weighed. 

Hydrochloride, mp 177-182. Water-soluble-thera cat Antiprotozoal (Histomonas). thera Cat (vet) Antimicrobial. 

Plants accumulate STLs as a means of chemical defence. Thus, one of the primary ecological benefits of these compounds is certainly the fact that they are toxic to all kinds of microorganisms. Once more it is their alkylant potency that is most obviously responsible. The work on antimicrobial activity of earlier years has been summarized in various reviews, e.g. [1-3]. More recent work has indicated that some STLs may have potential as leads for new antiprotozoal drugs. Apart from the prominent antimalarial artemisinin which will be treated separately in the following section, several more common STLs have been demonstrated to possess antiplasmodial [77-79], antileishmanial [80] and antitrypanosomal activity [81-84], Unfortunately, in most cases such activities are accompanied by high non-specific cytotoxicity so that it is always necessary to compare the antiprotozoal activity with cytotoxic effects determined under the same conditions. 

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