Antileukemia agents

L. D. Kissinger and N. L. Stemm, Determination of the antileukemia agents cytarabine and azacitidine and their respective degradation products by high-performance liquid chromatography, J. Chromatogr., 555 309 (1986). 

During the total synthesis of an antileukemia agent, control of the stereochemistry of the c ring formation has been established by a cesium fluoride mediated intramolecular conjugate addition of an a-face a-sulfonyl ester to an a-chloroenone (Scheme 79). ... 

Antileukemia agent with higher DNA binding capacity and greater cytoxicity than daunorubicin. 

The tricyclic cyclopenta[Z ]benzofuran skeleton of rocaglamide47 (an antileukemia agent extracted from Aglaia elliptifolid) has been successfully produced by sunlamp irradiation of 46 in the presence of diphenyldisulfide (equation 41). This work is connected to the... 

Maytansine (an antileukemia agent) and nine maytansinoid homologs (e.g., maytanbutine, maytanprine, maysenine, maysine, maytanacine, normaysine) were separated on a silica column (A = 254 nm) using a 95/2.5/2.5 dichloromethane/ dioxane/IPA mobile phase [793], Incomplete separation of compounds resulted, partly due to the very broad peaks. A small amount of strong acid (e.g., TFA) may sharpen peaks considerably. Elution was complete in 18 min. 

Compound 1 served as a key intermediate in the synthesis of [ C]imatinib (2), a drug with excellent efficacy for the treatment of chronic myelogenous leukemia. Other antileukemia agents were also labeled utilizing [ " C]cyanamide as a starting material (Figure 9.3). l/S-D-arabinofuranosyl[2- C]cytosine (5), for example, was prepared by... 

Wani MC, Tayler HI, Wall ME, Coggon P, McPhail AT. Plant antitumor agents. VI. The isolation and structure of taxol, a novel antileukemia and antitumor agent from Taxus brevifolia. J. Am. Chem. Soc. 1971 93 2325-2327. 

Holton RA, Nadizadeh H, Biediger RJ, Rengan K, Suzuki Y, Tao C, Chai K-B, Idmoumaz H (1994) Preparation of Taxanes Having Furyl or Thienyl Substituted Side-Chain as Antileukemia and Antitumor Agents. PCT Int Appl WO 94,21,651... 

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