Guanethidine Antihypertensives

Antipsychotics ACE inhibitors Beta biockers Cionidine Ciozapine + Antihypertensives Guanethidine + Antipsychotics Methyidopa... 

ImL sample) of 0.3 pgL" was claimed. The antihypertensive guanethidine (Figure 6.47) and the diuretic hydrochlorothiazide (Figure 6.50) have been measured simultaneously in pharmaceutical preparations using an ODS-modified silica column and ED (+1.3V V5 Ag/AgCl). The eluent was acetonitrile-aq. phosphate buffer (0.05 mol L ) (30 + 70) containing 20 nunol sodium pentane-sulfonate adjusted to pH 2.5. 

The amphetamines and the anorexiants should not be given during or within 14 days after administration of monoamine oxidase inhibitors (see Chap. 31) because the patient may experience hypertensive crisis and intracranial hemorrhage. When guanethidine is administered with the amphetamines or the anorexiants, the antihypertensive effect of guanethidine may decrease. Coadministration of the amphetamines or the anorexiants with the tricyclic antidepressants may decrease the effects of the amphetamines or the anorexiants. 

Guanethidine (77) was the first of a series of antihypertensive agents which act by interfering with adrenergic transmission. It was subsequently found that simple substitution of the guanidine function onto a nucleus with appropriate lipophilicity almost invariably affords such sympathetic inhibitors. 

Any broad-spectrum antibiotic Antihypertensives Reserpine Guanethidine Methyldopa Guanabenz Guanadrel... 

The azocane derivative guanethidine (5.99), an antihypertensive agent, is largely converted to the ot-amino acid metabolite without formation of a lactam metabolite [191], a reactivity that is difficult to explain. 

Antihypertensive Alpha methyldopa Clonidine Guanethidine Propranolol Reserpine... 

Synthetic guanidine derivatives have been used successfully in the treatment of a variety of diseases, but the major success has undoubtedly been their exploitation as antihypertensive drugs. Guanethidine has still not been displaced. 

Guanethidine (I) (p. 125) is a potent antihypertensive agent of great clinical importance [206]. A detailed discussion of the pharmacology of guanethidine is... 

The association of peak antihypertensive activity with the eight-membered ring of guanethidine rather than other ring sizes has been discussed previously... 

The antihypertensive activity of the seven-membered analogue of guanethidine in which a benzene ring is fused in the 4,5-position was reported in the review by... 

Included in this series of drugs are rezerpin, guanadrel, guanethidine, and metyrosine, and they are used mainly as antihypertensive drugs. 

Guanethidine is used for severe hypertension when the use of the more generally accepted drngs turns out to be unsuccessful. It is a powerful, long-lasting antihypertensive drug however, it affects a patient s blood pressure only in the orthostatic position, and not when lying down. 

The adrenergic neuron-blocking drugs are antihypertensive because they prevent the release of transmitters from peripheral postganglionic sympathetic nerves. The contraction of vascular smooth muscle due to sympathetic nerve stimulation is thereby reduced, and blood pressure decreases. Guanethidine is the prototypical member of this class. 

Guanethidine (Ismelin) is a powerful antihypertensive agent that is quite effective in the treatment of moderate to severe hypertension. It is most frequently used in the treatment of severe hypertension that is resistant to other agents. 

With the possible exception of minoxidil, guanethi-dine is the most potent orally effective antihypertensive drug. Because guanethidine produces a number of side effects that are due primarily to the imbalance between sympathetic and parasympathetic function it produces, it is generally reserved for the treatment of severe hypertension. 

The spectrum of activity of a-methyldopa (Aldomet) lies between those of the more potent agents, such as guanethidine, and the milder antihypertensives, such as reserpine. a-Methyldopa is a structural analogue of di-hydroxyphenylalanine (dopa) and differs from dopa only by the presence of a methyl group on the a-carbon of the side chain. 

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