Antiglutamatergics

In moderate to severe disease, consider adding antiglutamatergic therapy. 

Filliat, P., Baubichon, D., Burckhart, M.F., Pemot-Marino, L, Foquin, A., Masqueliez, C., Perrichon, C., Carpentier, P., Lallement, G. (1999). Memory impairment after soman intoxication in rat correlation with central neuropathology. Improvement with anticholinergic and antiglutamatergic therapeutics. Neurotoxicology 20 535-49. 

Coric V, Milanovic S, Wasyliiik S, Patel P, Malison R, Krystal JH (2003) Beneficial effects of tire antiglutamatergic agent riluzole in a patient diagnosed witlr obsessive-compulsive disorder and major depressive disorder. Psychophaimacology (Berl) 167 219—220. 

Ketter TA, Wang PW. The emerging differential roles of GABAergic and antiglutamatergic agents in bipolar disorders. J Chn Psychiatry 2003 64(Suppl 3) 15-20. 

B. A. Weissman and L. Raveh, Therapy against organophosphate poisoning the importance of anticholinergic drugs with antiglutamatergic properties, Toxicol. Appl. Pharmacol., 2008, 232, 351-358. 

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