Antigens, blood-group-related

Kawai T, Suzuki M, Torikata C, et al. Expression of blood group-related antigens and Helix pomatia agglutinin in malignant pleural mesothelioma and pulmonary adenocarcinoma. Hum Pathol. 1991 22 118-124. 

Zahler, P., Blood Group Antigens in Relation to Chemical and Structural... 

Syntheses of Core Chain Trisaccharides Related to Human Blood Group Antigenic Determinants, R. U. Lemieux, S. Z. Abbas, and B. Y. Chung, Can. J. Chem., 60 (1982) 68-75. 

The Preparation and a Comparison of Immunological Properties of Artificial Antigens Related to the Lewis a Human Blood Group. P. V. Nikrad, J. Pal, and R. U. Lemieux, Abstr, XIVth Int. Carbohydr. Symp., Stockholm, Sweden, August 14-19 (1988) C64. 

Structurally, the O-polysaccharide chains of H. pylori clinical isolates have a poly-A-acetyl-lactosamine (-LacNAc) chain decorated with multiple lateral a-L-fucose residues forming internal Lex determinants with terminal Lex or Ley units (Fig. 10.4) or, in some strains with additional, D-glucose or D-galactose residues (Moran 2001 a,b, 2008 Monteiro, 2001). Moreover, Lea, Leb, sialyl-Lex, and H-1 antigens have been structurally described in other strains, as well as the related blood groups A and B (Fig. 10.4), but occur in association with Lex and LacNAc chains (Monteiro et al., 2000a,b Heneghan et al., 2000). 

Lemieux RU, Bundle DR, Baker DA. The properties of a syn- 40. thetic antigen related to the human blood-group Lewis a. J. Am. 

TABLE 23-ii Blood Group Antigen-Related Gancet Markers ... 

Carbohydrate-related tumor markers either are (1) antigens on the tumor cell surface or (2) secreted by the tumor cells. Monoclonal antibodies have been developed against these antigens. These markers have been found to be clinically useful as tumor markers and tend to be more specific than naturally secreted markers, such as enzymes and hormones. Biochemically, they are high molecular weight mucins (Table 23-10) or blood group antigens (Table 23-11). 

---