A -fucose residue

These results suggest that, in addition to GM1 ganglioside, IMR-32 cells may contain some globoprotein and ganglioprotein (65) with terminal N-acetylgalactosamine (Table VII) and a-fucose residues (Table VIII) (65). Although we found very little activity of FucT-2 (Fig. 

The first total synthesis of a sialylated Lewis detenninant was reported by Palcic and her colleagues at the University of Alberta, Edmonton. In their biomimetic, combined oiganic-chemical and enzyme-catalyzed synthesis of the spacer-linked sLc pentaasaccharide 237, these authors followed the pathway of sLe biosynthesis previously discovered by Hansson and ZopC (Scheme 37). Hansson and Zopf found that microsomal preparations from the cell line S W 1116 catalyzed the transfer of a fucose residue from GDP- C fucose to position 4 of the GIcNAc residue of sialosylated lacto-A -tetraose a -D-Ncu5Acp-(2 3)-... 

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