Antigene sequences

Reineke, U., Kramer, A., and Schneider-Mergener, J. (1999). Antigen sequence- and library-based mapping of linear and discontinuous protein-protein interaction sites by spot synthesis. Curr. Top. Microbiol. Immunol. 243, 23-36. 

Antigene sequences and ribozymes form two additional classes of antisense agents. However, the therapeutic potential of these agents is only now beginning to be appraised. Certain RNA sequences can function as catalysts. These so-called ribozymes function to catalyse cleavage at specific sequences in a specific mRNA substrate. Many ribozymes will cleave their target mRNA where there exists a particular triplet nucleotide sequence G-U-C. Statistically, it is likely that this triplet will occur at least once in most mRNAs. 

Later Sweredoski et al. (37) incorporated a combination of amino acid propensity scores and half-sphere exposure values at multiple distances to form the BEpro tool (formerly called PEPITO). Using the Epitopia algorithm, Rubinstein et al. (38) for the first time truly exploited an extensive set of physicochemical and structural geometrical features from an antigen s primary or tertiary structures. They trained the Naive Bayes classifier using a benchmark dataset of 66 and 194 validated nonredundant epitopes derived from antibody-antigen structures and antigen sequences,... 

Saha S, Raghava G (2004) BcePred prediction of continuous B-cell epitopes in antigenic sequences using physico-chemical properties. In Proceedings of the 3rd international conference on artificial immune systems (ICARUS), 13-16 Sep 2004, Catania, Italy. LNCS 3239 197-204... 

Hedegaard K, Klemm P. Type 1 fimbriae of Escherichia coil as carriers of heterologous antigenic sequences, Gene, 85 115-124, 1989. 

Antibody with specificity for APC, which has an antigenic sequence inserted into a constant domain region. See Lunde, E., Lauvrak, V., Rasmussen,... 

In the case of the P. falciparum genes that we analyzed here, we noted that the biases in base composition of different codon positions, amino acid frequencies and codon preferences are almost identical in housekeeping and antigen sequences. If we take into account that both the level of expression and the evolutionary constraints over these sequences are most unlikely to be the same, it is reasonable to conclude (i) that the extremely biased composition of the genome (Poliak et al., 1982 McCutchan et al., 1984) is the major factor in determining codon preferences and amino acid frequencies and (ii) that the compositional constraints (Bernardi and Bernardi, 1986a) operate in the same direction over all the translated sequences and their codon positions (Musto et al., 1995, 1997, 1999). 

Figure 4.13 The Structures of Saccharides with Blood Group I and i Specificities. These are an example of the presence of antigenic sequences inside saccharide sequences, unlike A and B which are always terminal.

Perform stepwise assembly of the first antigenic sequence using standard Fmoc/tBu procedures, using a mixture of Fmoc-amino acid (0.4 mmol), TBTU (0.4 mmol), HOBt (0.2 mmol), and DIPEA (0.8 mmol). 

Typing of E. coli and Salmonella Strains Based on Flagellin H Antigen Sequences... 

ROSS N w, JOHNSON s c, FAST M D and EWART K V (2008), Recombinant Vaccines Against Caligid Copepods (Sea Lice) and Antigen Sequences Thereof, United States Patent Application 20080003233. http /Avww.freepatentsonline.coiii/y2008/ 0003233.html. Last accessed 16 October 2011. 

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