Antigen-presenting cells , cell-based

Muromonab is a mouse monoclonal antibody against the CD3 receptor of T-lymphocytes. Its activity is based on inhibition of interactions between antigen-presenting cells and T-cells. By preventing antigen presentation it suppresses T-cell activation and proliferation. The indication for muromonab is the treatment of acute graft rejection after kidney, liver and hart transplantations. Its adverse effects consist of those symptoms that are initiated by the release of cytokines and lymphokines as a result of the reaction of muromonab with CD3 positive T-lymphocytes. These symptoms may vary from a mild flu-like syndrome to serious cardiac, pulmonale and neurological reactions. 

Fitzmaurice, C.J., Brown, L.E., Kronin, K., and Jackson, D.C. (2000) The geometry of synthetic peptide-based immunogens affects the efficiency of T cell stimulation by professional antigen-presenting cells. Int. Immunol. 12, 527-535. 

In rheumatoid arthritis (RA), T cells play a critical role in both the cause and long-term maintenance of the disease. Tacrolimus, as a T-cell-specific immunosuppressant, should be effective against RA based on the pharmacological evidences that tacrolimus both inhibits the activation of T cells and blocks cross-talk between T cells and antigen-presenting cells [72]. 

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