Antigen-loss variants

Jager E, Ringhofier M, Karbach J, Arand M, Oesch F, Knuth A. Inverse relationship of melanocyte differentiation antigen expression in melanoma tissues and CD8+ cytotoxic-T-cell responses evidence for immunoselection of antigen-loss variants in vivo. Int J Cancer 1996 66 470 76. 

Peptide Vaccines tumor-specific antigens derived from the tumor tissue itself are used as vaccines against the tumor. This therapy has limited success because of the development of antigen-loss tumor variants and impaired HLA class I expression and antigen presentation [20]. 

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