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Antigen-binding fragment, antibody molecules

Figure 1.77 Disulfide reducing agents such as 2-mercaptoethylamine can be used to cleave the disulfide bonds in the hinge region of antibody molecules. Either intact IgG molecules or F(ab )2 fragments may be reduced in this manner to yield monofunctional antigen binding fragments. Figure 1.77 Disulfide reducing agents such as 2-mercaptoethylamine can be used to cleave the disulfide bonds in the hinge region of antibody molecules. Either intact IgG molecules or F(ab )2 fragments may be reduced in this manner to yield monofunctional antigen binding fragments.
The antibody molecule is based on a four-chain structure organized into three functional units (Fig. 7.2) (Padlan, 1993). Two of the units are identical and mediate binding to the antigen these regions are called the Fab (fragment antigen binding) arms of the antibody. The other unit, Fc... [Pg.82]


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Antibodies antibody fragments

Antibodies antibody molecules

Antibodies molecule

Antibody-antigen

Antibody-antigen binding

Antigen Molecules

Antigen-binding fragment, antibody

Antigens antigen-antibody binding

Antigens binding

Binding molecules

Fragments binding

Molecule fragments

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