Antifungal drugs essential

We first applied Tethering to thymidylate synthase (TS). This enzyme converts de-oxyuridine monophosphate (dUMP) to thymidine monophosphate (dTMP), an activity essential for DNA synthesis. The cancer drug 5-fluorouracil irreversibly inhibits TS, and a selective inhibitor of a non-human form of the enzyme could yield a new antibiotic or antifungal drug [23]. 

Roemer, T. et al. 2003. Large-scale essential gene identification in Candida albicans and applications to antifungal drug discovery. Mol. Microbiol. 50, 167-181. 

P-450 system Monitoring of circulating cyclosporine levels and appropriate dosage adjustment are essential when drugs that affect hepatic microsomal enzymes, particularly the cytochrome P-450 3A enzymes, are used concomitantly (eg, HIV protease inhibitors, anticonvulsants, azole antifungals). 

ZOl 13 Sharma, S. K., and V. P. Singh. The antifungal activity of some essential oils. Indian Drug Pharm Ind 1979 14(1) 3-6. 

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