Antiemetic drugs postoperative

Initiation of therapy - App y one system to the postauricular skin (ie, behind the ear) at least 4 hours before the antiemetic effect is required. To prevent postoperative nausea and vomiting, apply the patch the evening before scheduled surgery. To minimize exposure of the newborn baby to the drug, apply the patch 1 hour prior to cesarean section. Scopolamine approximately 1 mg will be delivered over 3 days. Wear only one disc at a time. Do not cut the patch. 

It causes antiemetic action by blocking dopamine (D receptors and it also increases gastric motility. It is absorbed orally but bioavailability is 15% due to first pass metabolism. It is completely biotransformed and metabolites are excreted in urine. It is used in nausea and vomiting in postoperative period, drug induced, radiation, uraemia, hepatitis, peptic ulcer. It is also useful in reflex oesophagitis. 

Tropisetron is a synthetic TTA containing an esterified tropine moiety (Fig. 1). This drug is a potent antiemetic selective 5-HT3 receptor antagonist to treat postoperative and chemotherapy-induced vomiting and nausea by daily intravenous or oral administration [70], Furthermore, tropisetron is a potent and selective partial agonist of a7-nAChR [39],... 

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