Antidotes organophosphate nerve agents

Organophosphate nerve agents inhibit the active site of AChE, a key enzymatic regulator of cholinergic neurotransmission. As noted in Chapter 5, Nerve Agents, agent-bound AChE can be reactivated by a class of antidote compounds, the oximes, which remove the nerve agent molecule from the catalytic site of AChE. 

PAM CL Pralidoxime, chloride, Protopam , is an antidote to organophosphate poisoning such as might result from exposure to nerve agents or some insecticides. The drug, which helps restore an enzyme called acetylcholinesterase, must be used in conjunction with atropine to be effective. Restores normal control of skeletal muscle contraction (relieves twitching and paralysis). 

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