Antidotes for organic phosphates

Antidotes for organic phosphates 636 Antienzymes 539 Antifreeze proteins 191 Antigen(s) 427 O-Antigen(s) 428... 

The active center of A. has two parts, the anionic binding site for the quatemaiy nitrogen (which is responsible for the alcohol specificity) and the esterase center (where a catalytic serine and histidine lyse the ester bond). The enzyme is inactivated by blockage of either the serine hydroxyl (by organic phosphate esters, such as diisopropylfluorophosphate or diethyl p-nitrophenylphosphate), or the anionic center by tri-methylammonium derivatives. If the enzyme has been blocked by organophosphates, it can be reactivated by pralidoxime salti which are therefore used as antidotes to organophosphate poisoning. 

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