Antidotes cobalt compounds

Cyanide s binding to metallic ions is also employed in a reaction with cobalt-containing compounds that yields cyanocobalamin (see Section 2.6). Cobalt compounds generally are not used because of their toxicity however, Co2EDTA (Klimmek et al. 1983) and hydroxocobalamin (Benabid et al. 1987 Mengel et al. 1989 Mushett et al. 1952) have been used as antidotes both in clinical and laboratory trials. Cardiac toxicity from Co2EDTA use under clinical conditions has raised caution in its clinical use, as the cardiac... 

Patients who are critical and do not satisfactorily respond to supportive therapy should be administered specific cyanide antidotes as outlined in Table 19.5. Cyanide antidotes have been classified into three main groups based on their mechanism of action (1) methemoglobin inducers, (2) sulfur donors, and (3) cobalt compounds. The definitive treatment of cyanide poisoning differs in various countries due to different medical practices and guidelines. The safety... 

LovattEvans C (1964). Cobalt compounds as antidotes for hydrocyanic acid. Br J Pharmacol, 23, 455-475. 

Successful antidotes for acute cyanide poisoning are available. Sodium thiosulfate, a sulfur donor, can detoxify HCN by promoting its conversion to thiocyanate when catalyzed by the enzyme rhodanase (Baumeister et al., 1975 Egekeze and Oehme, 1980) however, the detoxification effect is slow. Another procedure utilizes cobalt compounds (hydroxoco-balamine) to bind directly with cyanide to form physiologically inactive cyanocobalamine (Offterdinger and Weger, 1969). 

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