Teratogenicity antidepressants

Potential behavioral teratogenicity—the long-term effect of the medication on the functioning and behavior of the child many years later is an unknown factor for most medications used today, but no harm in this area is known for the antidepressants commonly prescribed. 

SAFETY PROFILE Poison by ingestion, intraperitoneal, and subcutaneous routes. Human systemic effects by ingestion ataxia, somnolence. An experimental teratogen. Experimental reproductive effects. Mutation data reported. Used as an antidepressant. When heated to decomposition it emits toxic fumes of NOx. 

Women comprise 51% of the population of most nations in Western countries, 54% of women are of child-bearing potential (15 9 years). Women account for 57% of physician visits (National Disease and Therapeutic Index ) (FDA, 1986). In the age group 20-39 years, women were found to be the biggest users of anti-infectives, especially ampicillin and amoxicillin antidepressants are prescribed twice as often to women as to men (Stewart, 1998) and of some concern was that tetracycline, a known teratogen, was the eighth most prescribed drug in this group most likely to bear children (FDA, 1986). 

Intense interest in the potential for SSRI antidepressants to have teratogenic and adverse pregnancy outcomes continues, and four further major data-based reports have appeared [19, 20P, 21, 22 ], as well as a report on the management of depression in pregnancy from two leading US professiorml bodies [23 ] and three leading editorials or commentaries [24 , 25 , 26 ]. 

Topiramate, cognitive reactions, 26.81 Topoisomerase inhibitors, 21 All Topotecan, 21 All Trocetrapib, 32.816 Transfusions AIDS, 12.298 complications, 12.300 Tretinoin, topical, teratogenicity, 18.164 Triazolam, 16.33 Tricyclic antidepressants endocrine reactions, 11.12 mania, 13.8... 

---