Tricyclic benzodiazepine anticholinergics

Opioids, benzodiazepines, barbiturates, corticosteroids, dopamine agonists (e.g., amantadine, bromocriptine, levodopa, pergolide, pramipexole, ropinirole), H2-receptor antagonists, anticholinergics (e.g., diphenhydramine, trihexylphenidyl), P-adrenergic blockers, clonidine, methyldopa, carbamazepine, phenytoin, baclofen, cyclobenzaprine, lithium, antidepressants (e.g., tricyclic antidepressants, selective serotonin reuptake inhibitors), and interleukin-2... 

A number of medications have been associated with an increased risk of falling, including drugs affecting mental status such as antipsychotics, benzodiazepines, tricyclic antidepressants, sedative-hypnotics, anticholinergics, and corticosteroids. Some cardiovascular and antihypertensive drugs also can contribute to falls, especially those causing orthostatic hypotension.9... 

The cardiovascular, CNS, and anticholinergic symptoms of phenothiazine toxicity are similar to, but generally much less severe than, those for the tricyclic antidepressants. Phe-nothiazines are relatively safe, and few deaths have occurred when toxic doses have been ingested alone. Much more severe toxicity occurs when phenothiazines are co-ingested with tricyclic antidepressant drugs or other CNS depressant drugs, such as ethanol, opioids, barbiturates, or benzodiazepines. 

Alprazoiam (Xanax) Benzodiazepine with anxiolytic activity. Mechanism of antidepressant effects unknown. Adjunct to tricyclic antidepressants for depression and panic attacks. No anticholinergic effeas. Does cause sedation and lethargy. ... 

---