Anticandidal activity

Hufford, C. D., Liu, S., Clark, A. M. and Oguntimein, B. O. 1987. Anticandidal activity of eupolauridine and onychine, alkaloids from Cleistopholispatens. Journal of Natural Products, 50 961-964. 

Fig. 1. Anticandidal activity of IV-benzyl aminocyclic urea PS-SCL. Each graph represents the activity of a sublibrary, and each bar within a graph represents the percent inhibition of the growth of C. albicans ATCC 10231 by a separate mixture. The line represents the average activity for all of the mixtures making up the corresponding sublibrary.

Anticandidal Activity of Most Active A-benzyl Aminocyclic Urea Mixtures... 

Cassone A, De Bemardis F, Torosantucci A, Tacconelli E, Tumbarello M, Cauda R In vitro and in vivo anticandidal activity of human immunodeficiency vims protease inhibitors. J. Infect Dis 1999 180 448 53. 

Kingsbury, W. D., Boehm, J. C., Mehta, R. J., Grappel, S. R Transport of antimicrobial agents using peptide carrier systems anticandidal activity of m-fluorophenylalanine peptide conjugates. J. Med. Chem. 1983,26,1725-1729. 

Cyathocaline exhibited moderate but selective activity in our yeast bioassay and also in a cytotoxicity assay against the A-549 human lung carcinoma cell line (Table 11). Three azafluorenone alkaloids have previously been tested for ( otoxic activity and were found to be inactive [53] but one has been reported to have anticandidal activity [54]. 

Substitution at position 4 will reduce the anticandidal activity, while some 4-substituted analogs retain activity against C. neoformans. 

Hufford CD, Liu S, Clark AM, Oguntimein BO. Anticandidal activity of eupolaur-idine and onychine, alkaloids from Cleistopholis patens. J Nat Prod 1987 50 961-4. 

In an effort to develop highly potent antifungal agents, Chauhan et al. [29] have reported potent antifungal rhodanine analogs. Some derivatives XXI, XXII, and XXIII were found to be very effective (MIC=0.78 pg/mL) against C. albicans MTCC183. The potent compoimds were further tested for in vitro anticandidal activity and amphotericin B-resistant strain of C. albicans. 

S. Sheikh, R.A. Sheikh, R. Bhatia, A.A. Hashmi, N. Manzoor, L.A. Khan, Anticandidal activity of ciimamaldehyde, its ligand and Ni (II) complex Effect of increase in ring and side chain, Microb. Pathogenesis 49 75-82, 2010. 

---