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Anticancer Saccharomyces cerevisiae

Our approach recently developed utilizes DNA repair- or recombination-deficient mutants of the yeast Saccharomyces cerevisiae [8]. An important feature of many tumor cells is that they have defects in their ability to repair damage to DNA as compared with normal cells, suggesting that agents with selective toxicity towards repair-deficient cells might be potential anticancer agents. [Pg.68]

JA Simon, P Szankasi, DK Nguyen, C Ludlow, HM Dunstan, CJ Roberts, EL Jensen, LH Hartwell, SH Friend. Differential toxicities of anticancer agents among DNA repair and checkpoint mutants of Saccharomyces cerevisiae. Cancer Res 60 328-333, 2000. [Pg.535]

See other pages where Anticancer Saccharomyces cerevisiae is mentioned: [Pg.142]    [Pg.85]    [Pg.188]    [Pg.328]    [Pg.941]    [Pg.413]    [Pg.462]    [Pg.84]    [Pg.202]    [Pg.1628]    [Pg.1648]    [Pg.241]    [Pg.329]   
See also in sourсe #XX -- [ Pg.63 , Pg.80 ]

See also in sourсe #XX -- [ Pg.63 , Pg.80 ]



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