Anticancer efficacy

Tardi P, Choice E, Masin D, Redelmeier T, Bally M, Madden TD. Liposomal encapsulation of topotecan enhances anticancer efficacy in murine and human xenograft models. Cancer Res 2000 60 3389. 

ArifJM, Kunhi M, Siddiqui YM, El Sayed KA, Orabi KY, Al-HazzaniA, Al-Ahdal MN, Al-Khodairy FM, Role of intermediary biomarkers in determining the anticancer efficacy of marine compounds, Medicinal Chemistry Research 13 553-562, 2004. 

Seymour, L. W., Ulbrich, K., Steyger, P. S., et al. Tumor tropism and anticancer efficacy of polymer-based doxorubicin prodrugs in the treatment of subcutaneous murine B16F10 melanoma. Br. J. Cancer 70 636-641, 1994. 

CDw52, a 21- to 28-kDa phosphatidylinositol-linked glycoprotein of unclear function, is widely expressed on the cell surface of both B and T lymphocytes (187). Anti-CDw52 mAbs include CAMPATH-1 and its humanized version CAMPATH-1H (187-188). CAMPATH-IH has been evaluated in multiple clinical trials, in which it has shown anticancer efficacy against a variety of lymphoid neoplasms (188-190). However, CAMPATH-IH also induced rapid depletion of both B cells and T cells, resulting in potentially profound immunosuppression (191). 

Granda, T., Levi, F. Tumor based rhythms of anticancer efficacy in experimental models. Chronobiol. Int. 2002,19 21 -1. 

Drug-loaded nanoparticles were also evaluated for their safety and efficacy. Paclitaxel-encapsulated 6-O-CAPRO-p-CD nanospheres and nanocapsules were evaluated for their physical stability in a one-month period in aqueous dispersion form with repeated particle size and zeta potential measurements and AFM imaging to evaluate recrystallization in aqueous medium. Paclitaxel-loaded amphiphilic CD nanoparticles were found to be physically stable for a period of one month whereas recrystallization occurs within minutes when diluted for intravenous (IV) infusion [85], Finally, paclitaxel-loaded amphiphilic nanoparticles were demonstrated to show similar anticancer efficacy against MCF-7 cells when compared to paclitaxel solution in a cremophor vehicle [85],... 

Soon after the introduction of vinblastine and vincristine in clinical usage, during the 1970 s, intensive chemical research was undertaken in order to try to obtain semi-synthetic derivatives of Vinca alkaloids showing higher activity, lower toxicity, and a wider spectrum of anticancer efficacy (for reviews see [16, 17]). 

WUliams NS, Burgett AWG, Atkins AS. Wang X, Harran PG, McKnight SL (2007) Therapeutic anticancer efficacy of a synthetic diazonamide analog in the absence of overt toxicity. PNAS 104 2074-2079... 

Jain AK, Swamakar NK, Das M et al (2011) Augmented anticancer efficacy of doxorubicin-loaded polymeric nanoparticles after oral administration in a breast cancer induced animal model. Mol Pharm 8 1140-1151... 

H. Soyez, L. W. Seymour and E. Schacht, Macromolecular derivatives of N,N-di-(2-chloroethyl)-4-phenylene diamine mustard. 2. In vitro cytotoxicity and in vivo anticancer efficacy, /. Control. Release, 57,187-196 (1999). 

Dasyukevich O, Solyanik G (2007) Comparative study of anticancer efficacy of aconitine-containing agent BC1 against ascite and solid forms of Erlich s carcinoma. Exp Oncol 4 317-319... 

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