Antibody selective association

Recent studies show that nucleosome/antinucleosome immune complexes contribute more to lupus nephritis. Serum anti-dsDNA reactivity is always associated with antinucleosome reactivity (A18, B26, B28, B29, C9). Even the highly purified monoclonal and polyclonal anti-dsDNA antibodies selected by affinity chromatography bind to isolated dsDNA and also to nucleosomes (C9, L23). Hybridoma-secreting anti-DNA can also form immune complexes in vitro with nucleosomes released from dying hybridomas in culture (F9). Finally, the binding of an anti-DNA antibody to a nucleosome may render the immune complex more positive and thereby make it more prone to bind to the GBM (T2). 

Eriksson BKG, Andersson J, Holm SE, Norgren M Invasive group A streptococcal infections T1M1 isolates expressing pyrogenic exotoxins A and B in combination with selective lack of toxin-neutralizing antibodies are associated with increased risk of streptococcal toxic shock syndrome. J Infect Dis 1999 1X0 410 -IIS. 

Wessels, B.W., and Rogus, R.D. (1984) Radionuclide selection and model absorbed dose calculations for radiolabeled tumor associated antibodies. Med. Phys. 11, 638-645. 

Clear identification of tumour-associated antigens would facilitate the production of monoclonal antibodies capable of selectively binding to tumour tissue. Such antibodies could be employed to detect and/or destroy the tumour cells. 

In mature neutrophils, interferon-7induces the expression of FC7RI, increases antibody-dependent cytotoxicity, primes the ability to generate reactive oxidants and selectively stimulates protein biosynthesis. These effects are described in detail in Chapter 7. Additionally, this cytokine has been used clinically for the treatment of chronic granulomatous disease (CGD), which is associated with an increased susceptibility to infections due to an impairment of NADPH oxidase function ( 8.2). 

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