Antibiotics nucleic acid synthesis inhibitors

I.2.4.3 Nucleic Acid Synthesis Inhibitors This mechanism is best exemplified by quinolone antibiotics. The basic structure of aU quinolone antibiotics is similar, with an exocyhc oxygen at position 4. The core structure is ... 

Bacterial infections are treated with antibiotics. There are many antibiotics available, but they fall into three major groups based on their mode of action inhibitors of bacterial nucleic acid synthesis inhibitors of cell wall synthesis and inhibition of bacterial protein synthesis. Resistance of bacteria to commonly-used antibiotics has become a major problem necessitating the development of new antibiotics. Tuberculosis infection is difficult to treat and requires a combination of at least three different antibiotics. 

Inhibitors of nucleic acid synthesis 3.6 Antibiotics with other resistance... 

Triostins, A quinoxatlne antibiotic complex sim -ilar to echinomycin, v. Powerful, selective inhibitor of nucleic acid synthesis in vitro, isoin of triostin C from Strep-tomyces S-2-2IO resembling S, aureus J. Shoji, K. Katagiri,... 

Antibacterial antibiotics can be broadly classified according to their specific site and mode of action as inhibitors of (1) respiration and (or) oxidative phosphorylation, (2) cell-wall mucopeptide synthesis, (3) cell membrane function, (4) nucleic acid synthesis, (5) protein synthesis, and (6) miscellaneous antibiotics. 

Reviews - Relevant reviews have appeared in the last few years on the subject dealing specifically with the mechanism of action of different antimicrobial drugs and antibiotics inhibitors of the bacterial ribosome i inhibitors of protein and nucleic acid synthesis and inhibitors as tools in cell research. ... 

Antibiotics as Inhibitors of Nucleic Acid and Protein Synthesis G. Hartmann et al., Angew. Chem., Int. Ed. Engl., 1968, 7, 693-701. 

H. R. Perkins and M. Nieto, Pure Appl. Chem. 35, 371-381 (1973). Antibiotics as inhibitors of nucleic acid and protein synthesis ... 

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