Antibacterial property chemical modifications

It is better to label the PRPs at the C-terminus. In our experience, if the peptide is labelled to the N-terminus we often noticed a significant decrease in antimicrobial activity. Before using labelled PRPs, it is in any case advisable to check whether this chemical modification has altered its antimicrobial activity compared with that of the unmodified molecule by both MIC and growth inhibition assays (see Subheading 3.5). In our experience the addition of the BODIPY to the C-terminus of Bac7(l-35) did not modify its antibacterial properties. 

A variety of chemical modifications at the C-20 aldehyde group in tylosin and related macrolides have been reported [206]. The C-20 aldehyde can be radically modified or removed entirely without reducing the antibiotic activity. Reductive amination of C-20 aldehyde of tylosin and related macrolides has yielded a large group of derivatives with useful antibiotic properties. Omura et al. reported that 20-deoxy-20-aminotylosin and 20,20 -dideoxo-iminotylosin had lower antibacterial... 

Surface modification of a fiber can be accomplished by chemical treatment, graft copolymerization, ion implantation, or plasma treatment. Surface modification usually targets improvements in antistatic properties, moisture regain, dyeing, printing, adhesion, abrasion, antibacterial properties, and so forth. 

Table 17.2 lists chemical and physical surface modifications used to impart antibacterial properties on PU (Kugel et al., 2011). 

Although changing the chemistry of the surface undoubtedly has a drastic improvement in antibacterial properties, the downstream approval process becomes more cumbersome with each chemical modification. An alternative approach is to change only the physical features of the surface by etching with acid and studying the resultant... 

Modification by the incorporation of metals or metalloids, styrene, vinyl acetate, poly(styrene-co-maleic anhydride), urethane linkages, and so on result in poly(ester amide) resins with good chemical properties and excellent thermal resistance. Some can also be used as effective antibacterial and biologically safe corrosion protective coating materials. Urethane-modified ethylenediamine tetraacetic add the fatty amide diol of linseed oil-based poly(ester amide) resin exhibits excellent physicomechanical properties, high thermostability up to 200°C and anticorrosive properties. ... 

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